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*McAfee: Main [[Thunderbird:Testing:Antivirus_Related_Performance_Issues#McAfee|McAfee topic below]] [https://support.mozilla.org/en-US/questions/1094984 McAfee Active Protection] {{bug|544684}} shutdown hang, [https://getsatisfaction.com/mozilla_messaging/topics/thunderbird_is_slow_to_launch slow startup], {{bug|1015437}} Slow getting mail
*Microsoft Security Essentials aka MSE (Settings | Excluded Files & Folders | add [https://support.mozillamessaging.com/en-US/kb/profiles#w_where-is-my-profile-stored your profile folder], typically c:\users\-your-user-name-\appdata\roaming\thunderbird **) [http://getsatisfaction.com/mozilla_messaging/topics/thunderbird_very_slow_with_microsoft_security_essentials?utm_content=reply_link&utm_medium=email&utm_source=reply_notification#reply_12390513] [https://getsatisfaction.com/mozilla_messaging/topics/thunderbird_slow-yvp58] [http://groups.google.com/group/mozilla.support.thunderbird/browse_thread/thread/93ab6d849bd87918] [http://groups.google.com/group/mozilla.support.thunderbird/browse_thread/thread/84767c1397f8d560/d2ec367b9d781522?lnk=raot] [https://getsatisfaction.com/mozilla_messaging/topics/thunderbird_very_slow_with_microsoft_security_essentials] [https://getsatisfaction.com/mozilla_messaging/topics/thunderbird_very_slow_on_one_system_and_fast_on_another] [https://support.mozilla.org/en-US/questions/1289514] {{Bug|621083}} [https://bugzilla.mozilla.org/show_bug.cgi?id=839908#c7 Bug 839908]
* Microsoft Windows Defender aka "Antimalware Service Executable" (ASE) aka MsMpEng.exe - ** '''[https://support.microsoft.com/en-us/windows/add-an-exclusion-to-windows-security-811816c0-4dfd-af4a-47e4-c301afe13b26#:~:text=Go%20to%20Start%20%3E%20Settings%20%3E%20Update,%2C%20file%20types%2C%20or%20process. create Create an exception to exclude] the [https://support.mozilla.org/en-US/kb/profiles-where-thunderbird-stores-user-data Thunderbird profile directory/folder]and also C:\Program Files\Mozilla Thunderbird\thunderbird.exe. ''' **User reports of slowness fixed by creating an exclusion for the Thunderbird profile folder. [https://www.reddit.com/r/Thunderbird/comments/1eo41qa/comment/lhcb6fa/ Multiple reports], [https://www.reddit.com/r/Thunderbird/comments/1evmnz6/having_terrible_lagfreezing_only_when_downloading/], [https://support.mozilla.org/en-US/questions/1355808#answer-1461964], [https://bugzilla.mozilla.org/show_bug.cgi?id=1208116#c5], [https://support.mozilla.org/en-US/questions/1067704], [https://support.mozilla.org/en-US/questions/1152667], [https://support.mozilla.org/en-US/questions/1013191], [https://superuser.com/questions/1324436/system-slow-unresponsive-when-thunderbird-is-receiving-emails-with-windows-defen], [https://support.mozilla.org/en-US/questions/1285317], {{bug|1441918}} (Firefox), {{bug|1640725}}, [https://www.reddit.com/r/Thunderbird/comments/mbspvh/comment/ihbx4lb/?utm_source=reddit&utm_medium=web2x&context=3]
*Panda Cloud Anti Virus Free v 2. Installed but it interfered with sending emails. Thunderbird v 24.3.0 said it could not access the temp directory although the outgoing emails were there. Thus the mail was not sent. No apparent tweaks worked. When Panda uninstalled, Thunderbird was back to normal.
*pctools internet security 2011 {{bug|610106}}
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